Balat O, Balat A, Verschraegen C, Tornos C, Edwards C L
University of Texas, Anderson Cancer Center, Department of Gynecologic Oncology, Houston, USA.
Eur J Gynaecol Oncol. 1996;17(5):335-7.
Sarcoma botryoides, a variant of embryonal rhabdomyosarcoma, is the most common neoplasm of the lower genital tract in girls under 16 years of age. This neoplasm more frequently has a vaginal location in patients younger than 4 years, whereas a cervical location has its peak incidence in the second decade. Although the recommended therapy has been radical surgery alone or combined with other modalities, the use of neoadjuvant chemotherapy has changed the surgical approach to one employing a less radical procedure such as a simple hysterectomy or local excision. We present the case of a 12-year-old girl diagnosed with an embryonal rhabdomyosarcoma of the endocervix who received vincristine-Adriamycin-cyclophosphamide combination chemotherapy followed by a simple hysterectomy. The patient exhibits no evidence of disease 8 years after the initial diagnosis.
葡萄状肉瘤是胚胎性横纹肌肉瘤的一种变体，是16岁以下女孩下生殖道最常见的肿瘤。该肿瘤在4岁以下患者中更常发生于阴道，而宫颈部位的发病高峰在第二个十年。尽管推荐的治疗方法是单纯根治性手术或与其他方式联合使用，但新辅助化疗的应用已将手术方式改变为采用不太激进的手术，如单纯子宫切除术或局部切除术。我们报告一例12岁女孩，诊断为宫颈胚胎性横纹肌肉瘤，接受长春新碱-阿霉素-环磷酰胺联合化疗，随后行单纯子宫切除术。初始诊断8年后，该患者无疾病证据。
