Spona J, Feichtinger W, Kindermann C, Wünsch C, Brill K
First Department of Obstetrics and Gynecology, Ludwig Boltzmann-Institute for Experimental Endocrinology, University of Vienna, Austria.
Contraception. 1996 Nov;54(5):299-304. doi: 10.1016/s0010-7824(96)00183-7.
Twenty-four healthy female volunteers with normal ovulatory cycles, aged between 20 and 34 years (27.5 +/- 4.3), were included in a single-center, non-comparative study to investigate the effect on inhibition of ovulation of an oral contraceptive containing 20 micrograms ethinylestradiol in combination with 100 micrograms levonorgestrel. At baseline, during three treatment cycles and post-treatment, ultrasonography was used to examine the ovaries, to measure follicular size, and to measure the thickness of the endometrium. Serum levels of LH, FSH, estradiol, progesterone, total testosterone, free testosterone, SHBG, and CBG were also measured. Compared with treatment cycle 1, an increase in residual ovarian activity (follicle grades 4-5) was observed in cycles 2 and 3. Mean levels of LH, FSH, 17 beta-estradiol and progesterone remained suppressed during treatment. No escape ovulation was observed during the treatment phase of the study and there were no pregnancies. Ovulation was noted to return rapidly in the posttreatment cycle. Subjective and objective tolerance of the present regimen was noted to be good. Results indicate that the monophasic oral contraceptive containing 100 micrograms levonorgestrel combined with 20 micrograms ethinylestradiol effectively inhibits ovulation, providing adequate suppression of ovarian activity.
24名排卵周期正常、年龄在20至34岁之间（27.5±4.3）的健康女性志愿者参与了一项单中心、非对照研究，以调查一种含有20微克炔雌醇和100微克左炔诺孕酮的口服避孕药对排卵抑制的影响。在基线期、三个治疗周期期间及治疗后，使用超声检查卵巢、测量卵泡大小及子宫内膜厚度。还测量了血清促黄体生成素（LH）、促卵泡生成素（FSH）、雌二醇、孕酮、总睾酮、游离睾酮、性激素结合球蛋白（SHBG）和皮质类固醇结合球蛋白（CBG）的水平。与第1个治疗周期相比，在第2和第3个周期观察到残余卵巢活性增加（卵泡4 - 5级）。治疗期间，LH、FSH、17β-雌二醇和孕酮的平均水平仍受到抑制。在研究的治疗阶段未观察到突破性排卵，也没有妊娠情况。注意到排卵在治疗后周期迅速恢复。本方案的主观和客观耐受性良好。结果表明，含有100微克左炔诺孕酮与20微克炔雌醇的单相口服避孕药可有效抑制排卵，对卵巢活性提供充分抑制。
