Haberman Ann M, Shlomchik Mark J
Department of Laboratory Medicine, Yale University School of Medicine, New Haven, Connecticut 06510, USA.
Nat Rev Immunol. 2003 Sep;3(9):757-64. doi: 10.1038/nri1178.
The close association of follicular dendritic cells (FDCs) and germinal-centre B cells has fostered the idea that B-cell recognition of retained antigen that is presented on the surface of FDCs is important for affinity maturation and memory B-cell development. We argue that the retention of immune complexes is not required for germinal-centre development, affinity maturation and memory B-cell maintenance. Instead, it is probable that FDCs support B-cell proliferation and differentiation in a non-specific manner. Other potential roles of immune complexes retained by FDCs are discussed.
滤泡树突状细胞（FDCs）与生发中心B细胞的紧密关联催生了这样一种观点，即B细胞识别FDCs表面呈递的留存抗原对于亲和力成熟和记忆B细胞的发育很重要。我们认为，生发中心的发育、亲和力成熟和记忆B细胞的维持并不需要免疫复合物的留存。相反，FDCs很可能以非特异性方式支持B细胞的增殖和分化。文中还讨论了FDCs留存的免疫复合物的其他潜在作用。
