Humphreys-Beher M G
Department of Oral Biology, University of Florida, Gainesville 32610, USA.
Adv Dent Res. 1996 Apr;10(1):73-5. doi: 10.1177/08959374960100011501.
Numerous models of exocrine tissue pathology related to autoimmune initiation of disease have been described, primarily by either immunohistology or histopathology. These model systems include inbred mouse strains that develop systemic lupus erythematosus, rheumatoid arthritis, graft vs. host disease, and diabetes. Commonly observed features of these mice include organized lymphocytic foci, composed of CD4+ and CD8+ T-cells, in both the salivary and the lacrimal glands. However, only the diabetic mouse model (NOD) undergoes a corresponding loss in exocrine gland function related to the presence of lymphocytic infiltrates. As we define the underlying pathophysiology of Sjögren's syndrome, the future of animal models for this disease will involve genetic exploration of candidate genes for development of autoimmune exocrinopathy.
已经描述了许多与自身免疫性疾病起始相关的外分泌组织病理学模型，主要通过免疫组织学或组织病理学方法。这些模型系统包括发生系统性红斑狼疮、类风湿性关节炎、移植物抗宿主病和糖尿病的近交系小鼠品系。这些小鼠常见的特征包括在唾液腺和泪腺中由CD4 +和CD8 + T细胞组成的有组织的淋巴细胞灶。然而，只有糖尿病小鼠模型（非肥胖糖尿病小鼠）会因淋巴细胞浸润而出现相应的外分泌腺功能丧失。随着我们对干燥综合征潜在病理生理学的定义，这种疾病动物模型的未来将涉及对自身免疫性外分泌病发展候选基因的遗传学探索。
