口服三唑仑术前用药对高度焦虑牙科患者的疗效及记忆效应
The efficacy and memory effects of oral triazolam premedication in highly anxious dental patients.
作者信息
Milgrom P, Quarnstrom F C, Longley A, Libed E
机构信息
Department of Dental Public Health Sciences, University of Washington, Seattle 98195-7475, USA.
出版信息
Anesth Prog. 1994;41(3):70-6.
Abstract
Triazolam (0.375 or 0.50 mg) or placebo was administered orally to 31 highly anxious dental patients in a double-blind clinical trial 1 hr before treatment. The drug was safe and highly effective, in comparison to placebo, in reducing both anxious cognitions and disruptive movement during oral injections of local anesthetic and drilling. Episodic memory and implicit memory were both adversely affected by the active drug but not the placebo.
摘要
在一项双盲临床试验中，在治疗前1小时给31名高度焦虑的牙科患者口服三唑仑（0.375毫克或0.50毫克）或安慰剂。与安慰剂相比，该药物在减少局部麻醉剂注射和钻孔过程中的焦虑认知和干扰性动作方面安全且高效。活性药物对情景记忆和内隐记忆均有不利影响，但安慰剂无此影响。
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