Specht E E
J Bone Joint Surg Br. 1977 Aug;59(3):349-51. doi: 10.1302/0301-620X.59B3.893513.
A computerised image analyser has been used experimentally to determine its possible usefulness in quantifying bone density. Rats were prepared for this purpose and ash weight/volume readings were obtained on femora which had been radiographed and studied to estimate radiographic density by means of the image analyser. The findings indicated that rats can be prepared by administering oestradiol or by allowing an additional week's growth, both of which give a statistically significant increase of bone density. The computerised image analyser was able to detect these differences but the correlations, although real and linear, between ash weight/volume and radiographic density were not large. Further refinements in techniques will be needed before the system is applied clinically.
已通过实验使用计算机图像分析仪来确定其在量化骨密度方面的潜在用途。为此准备了大鼠，并对已进行X光摄影的股骨进行灰重/体积读数，通过图像分析仪对其进行研究以估计放射密度。研究结果表明，可通过给予雌二醇或让大鼠再生长一周来制备大鼠，这两种方法均可使骨密度在统计学上显著增加。计算机图像分析仪能够检测到这些差异，但灰重/体积与放射密度之间的相关性虽然真实且呈线性，但并不显著。在该系统应用于临床之前，还需要进一步改进技术。
