Beckett C G, Hill P, Hine K R
Department of Medicine, Princess Royal Hospital, West Sussex, UK.
Postgrad Med J. 1996 Jul;72(849):437-8. doi: 10.1136/pgmj.72.849.437.
We report the case of a 77-year-old man admitted nine days after being commenced on azathioprine with symptoms initially thought to be secondary to sepsis but in fact due to azathioprine hypersensitivity. He developed histologically proven cutaneous leucocytoclastic vasculitis following the re-introduction of azathioprine. We review the literature concerning adverse reactions to azathioprine and the problems of making the diagnosis as well as highlighting azathioprine as a novel cause of leucocytoclastic vasculitis.
我们报告了一例77岁男性患者的病例，该患者在开始使用硫唑嘌呤九天后入院，其症状最初被认为是败血症继发症状，但实际上是由于硫唑嘌呤过敏所致。在重新使用硫唑嘌呤后，他出现了经组织学证实的皮肤白细胞破碎性血管炎。我们回顾了有关硫唑嘌呤不良反应及诊断问题的文献，并强调硫唑嘌呤是白细胞破碎性血管炎的一个新病因。
