Cao Sissi, Sun Dongmei
University of Western Ontario Schulich School of Medicine and Dentistry, London, Ontario, Canada.
Department of Internal Medicine, Western University, London, Ontario, Canada.
BMJ Case Rep. 2017 Jul 14;2017:bcr-2016-217755. doi: 10.1136/bcr-2016-217755.
Influenza vaccinations are commonly administered and effectively prevent influenza. Most vaccine reactions are mild and self-limiting with few reported cases of vasculitis. We present a case of vasculitis post-vaccination unique for its dramatic visual presentation and rapid response to treatment with the aim to emphasise possible causation and timely treatment.
This is a case of a 60-year-old man with chronic idiopathic pulmonary fibrosis, with fever, arthralgias and rash characterised by extensive erythematous plaques on his limbs and trunk 5 days after influenza vaccination. Skin biopsy revealed leucocytoclastic vasculitis. Rash and symptoms resolved 10 days after initiating treatment with oral prednisone.
Influenza vaccines can potentially precipitate cutaneous vasculitis, and timely treatment reduces morbidity in the elderly.
流感疫苗接种普遍，能有效预防流感。大多数疫苗反应轻微且为自限性，报告的血管炎病例较少。我们报告一例接种疫苗后发生的血管炎病例，其独特之处在于显著的视觉表现和对治疗的快速反应，旨在强调可能的病因及及时治疗。
这是一名60岁患有慢性特发性肺纤维化的男性患者，在接种流感疫苗5天后出现发热、关节痛和皮疹，其特征为四肢和躯干有广泛的红斑性斑块。皮肤活检显示白细胞破碎性血管炎。口服泼尼松治疗10天后皮疹和症状消退。
流感疫苗可能诱发皮肤血管炎，及时治疗可降低老年人的发病率。
