[肥厚型心肌病的产前研究及其与糖尿病母亲胎儿胰岛素水平的关联]

[Prenatal study of hypertrophic cardiomyopathy and its association with insulin levels in fetuses of diabetic mothers].

作者信息

Hagemann L L, Zielinsky P

机构信息

Instituto de Cardiologia do RS--Unidade de Pesquisa, Porto Alegre, RS.

出版信息

Arq Bras Cardiol. 1996 Apr;66(4):193-8.

PMID:8935683

Abstract

PURPOSE

To test the hypothesis that hypertrophic cardiomyopathy during prenatal life in diabetic pregnancies is related to fetal hyperinsulinism.

METHODS

Thirty seven fetuses of diabetic mothers and 28 of non-diabetic mothers were studied by echocardiography and fetal insulin levels measured.

RESULTS

Mean fetal insulin levels were 22.16 (+/- 44.25) microU/ml (3.20 to 240 microU/ml) in the group with diabetes and 6.50 (+/- 3.45) microU/ml (3.10 to 17.00 microU/ml) in the control group (p = 0.004). Ten out of 37 fetuses of the diabetic group were considered to have hypertrophic cardiomyopathy (27.02%), while none of the fetuses of the control group showed increase in septal thickness (p = 0.001). A significant association between prenatal hypertrophic cardiomyopathy and fetal hyperinsulinism was demonstrated (p = 0.013).

CONCLUSION

There is an association between hypertrophic cardiomyopathy and high levels of fetal insulin.

摘要

目的

验证糖尿病妊娠期间胎儿肥厚型心肌病与胎儿高胰岛素血症相关这一假说。

方法

通过超声心动图对37例糖尿病母亲的胎儿和28例非糖尿病母亲的胎儿进行研究，并测量胎儿胰岛素水平。

结果

糖尿病组胎儿平均胰岛素水平为22.16（±44.25）微单位/毫升（3.20至240微单位/毫升），对照组为6.50（±3.45）微单位/毫升（3.10至17.00微单位/毫升）（p = 0.004）。糖尿病组37例胎儿中有10例被认为患有肥厚型心肌病（27.02%），而对照组胎儿均未出现室间隔增厚（p = 0.001）。产前肥厚型心肌病与胎儿高胰岛素血症之间存在显著关联（p = 0.013）。