van der Sande F M, Hillen H F
Department of Internal Medicine, Catharina Hospital, Eindhoven, Netherlands.
Neth J Med. 1996 Mar;48(3):92-5. doi: 10.1016/0300-2977(95)00049-6.
We report the clinical efficacy of granulocyte colony-stimulating factor (G-CSF) in a 17-year-old woman with Shwachman's syndrome who was repeatedly admitted with severe infections and neutropenia. Bone marrow culture showed no increase in granulocyte colony-forming units upon stimulation with granulocyte-macrophage colony-stimulating factor (GM-CSF). The patient was treated with G-CSF 300 micrograms 3 times a week subcutaneously. A complete and sustained response of the neutropenia was obtained without side-effects during 21 months of treatment. No infectious episodes were encountered after starting G-CSF. This observation demonstrates the beneficial effect of G-CSF in treating the severe neutropenia in patients with Shwachman's syndrome.
我们报告了粒细胞集落刺激因子（G-CSF）对一名17岁患有施瓦茨曼综合征女性的临床疗效，该患者因严重感染和中性粒细胞减少症反复入院。骨髓培养显示，用粒细胞-巨噬细胞集落刺激因子（GM-CSF）刺激后，粒细胞集落形成单位没有增加。患者接受皮下注射G-CSF 300微克，每周3次治疗。在21个月的治疗期间，中性粒细胞减少症得到了完全且持续的缓解，且无副作用。开始使用G-CSF后未再发生感染发作。该观察结果证明了G-CSF在治疗施瓦茨曼综合征患者严重中性粒细胞减少症方面的有益作用。
