Spencer T J, Biederman J, Harding M, O'Donnell D, Faraone S V, Wilens T E
Pediatric Psychopharmacology Unit (ACC 725), Massachusetts General Hospital, Boston 02114, USA.
J Am Acad Child Adolesc Psychiatry. 1996 Nov;35(11):1460-9. doi: 10.1097/00004583-199611000-00014.
To reevaluate the hypothesis that stimulants cause growth deficits in children with attention-deficit hyperactivity disorder (ADHD).
Growth deficits in height and weight were examined in 124 children and adolescents with ADHD and 109 controls, using appropriate correction by age and parental height measures and attending to issues of pubertal stage, treatment, and psychiatric comorbidity.
Small but significant differences in height were identified between ADHD children and controls. However, height deficits were evident in early but not late adolescent ADHD children and were unrelated to use of psychotropic medications. There was no evidence of weight deficits in ADHD children relative to controls, and no relationship between measures of malnutrition and short stature was identified.
ADHD may be associated with temporary deficits in growth in height through mid-adolescence that may normalize by late adolescence. This effect appears to be mediated by ADHD and not its treatment.
重新评估兴奋剂会导致注意力缺陷多动障碍(ADHD)儿童生长发育迟缓这一假说。
对124名患有ADHD的儿童和青少年以及109名对照者的身高和体重生长发育迟缓情况进行了检查,采用年龄和父母身高测量的适当校正方法,并关注青春期阶段、治疗和精神共病问题。
ADHD儿童与对照者之间在身高上存在微小但显著的差异。然而,身高不足在青春期早期的ADHD儿童中明显,但在青春期晚期则不明显,且与使用精神药物无关。没有证据表明ADHD儿童相对于对照者存在体重不足,也未发现营养不良与身材矮小测量指标之间存在关联。
ADHD可能与青春期中期之前的身高生长暂时迟缓有关,到青春期晚期可能恢复正常。这种影响似乎是由ADHD介导的,而非其治疗。