Del Rosso J Q
J Am Osteopath Assoc. 1996 Oct;96(10):607-9.
A 40-year-old woman had a 10-year history of dermatophyte-related toenail onychomycosis (tinea unguium) and dry-type tinea pedis, which had failed to respond to previous therapy with topical antifungal agents or oral griseofulvin. The patient was successfully treated with four cycles of intermittent itraconazole therapy (that is, 400 mg/d for 1 week per month for 4 months). At the end of this time, the tinea pedis had resolved and the onychomycosis improved significantly after four cycles were completed. Twelve months after the onset of therapy, both conditions had resolved completely according to both clinical and mycologic criteria. Itraconazole was well tolerated, with no side effects reported. These observations suggest that itraconazole intermittent dosing is a highly effective therapy for the treatment of onychomycosis caused by dermatophyte organisms, because it provides a high cure rate after only a short course of therapy.
一名40岁女性有10年皮肤癣菌相关的趾甲甲癣（甲癣）和干性足癣病史，既往使用外用抗真菌药或口服灰黄霉素治疗均无效。该患者通过四个周期的间歇性伊曲康唑治疗（即每月1周，400mg/d，共4个月）获得成功治疗。治疗结束时，足癣已消退，完成四个周期后甲癣明显改善。治疗开始12个月后，根据临床和真菌学标准，两种病症均已完全消退。伊曲康唑耐受性良好，未报告有副作用。这些观察结果表明，伊曲康唑间歇给药是治疗由皮肤癣菌引起的甲癣的高效疗法，因为仅经过短疗程治疗就能获得高治愈率。
