Ohara R, Kawamoto M, Okada K, Yuge O
Department of Anesthesiology and Critical Care, Hiroshima University School of Medicine.
Masui. 1996 Oct;45(10):1209-11.
Both atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) are considered to play a role in regulation of body fluid volume and blood pressure. Serial changes of their plasma concentrations are known to reflect blood volume. In this study, we investigated the serial changes in maternal blood concentrations of ANP and BNP in those who underwent cesarean section under spinal anesthesia. Blood samples were obtained before anesthesia, before surgery, at the end of surgery, and on the next morning. Samples were also compared with those from normal pregnant women. Throughout the cesarean section, ANP did not show any significant changes, while BNP remained within normal ranges during anesthesia and increased on the next morning. We concluded that ANP and BNP were regulated differentially, and that BNP reflected blood volume significantly during and after spinal anesthesia.
心房利钠肽（ANP）和脑利钠肽（BNP）都被认为在体液容量和血压的调节中发挥作用。已知它们血浆浓度的系列变化反映血容量。在本研究中，我们调查了在脊髓麻醉下接受剖宫产的产妇血液中ANP和BNP浓度的系列变化。在麻醉前、手术前、手术结束时及次日早晨采集血样。还将这些样本与正常孕妇的样本进行比较。在整个剖宫产过程中，ANP没有显示出任何显著变化，而BNP在麻醉期间保持在正常范围内，并在次日早晨升高。我们得出结论，ANP和BNP受到不同的调节，并且BNP在脊髓麻醉期间及之后能显著反映血容量。
