Hoshino K, Nakamura M, Kamoshita N, Ikeda H, Kobayashi J, Tanaka T, Koyama T, Morishita Y
Dept. of Surgery, Imai Hospital.
Gan To Kagaku Ryoho. 1996 Nov;23(13):1841-5.
A 40-year-old woman was admitted to the hospital because of dysphagia and severe anemia (Hb 4.5 g/dl). She was diagnosed as having an advanced gastric cancer, which was unresectable because of liver metastasis, esophageal invasion and paraaortic lymph node metastasis. Combination chemotherapy with CDDP/5'-DFUR was started. CDDP of 80 mg/m2 was administered twice every 4 weeks by a 24-hour drip infusion method, and oral 5'-DFUR of 1,400 mg/m2 was administered for 4 days prior to the first administration of CDDP. Then, 5'-DFUR of 500 mg/m2 was given every day except for 7 days after the first administration of CDDP. Her performance status before the chemotherapy was 3, and improved to 1 a month after the first administration of CDDP. The patient was discharged very much improved on the 45th day after the first administration of CDDP. The side effect was nausea but tolerable. Six months after the first administration, her cancer disappeared on X-ray films, endoscopic and CT examinations. Her PS improved to 0, and she has remained alive with a good QOL for 10 months after the second administration of CDDP.
一名40岁女性因吞咽困难和严重贫血（血红蛋白4.5g/dl）入院。她被诊断为晚期胃癌，由于肝转移、食管侵犯和主动脉旁淋巴结转移而无法切除。开始采用顺铂/去氧氟尿苷联合化疗。顺铂80mg/m²每4周通过24小时持续静脉滴注法给药两次，在首次给予顺铂前4天口服去氧氟尿苷1400mg/m²，共4天。然后，除首次给予顺铂后的7天外，每天给予去氧氟尿苷500mg/m²。化疗前她的体能状态评分为3分，首次给予顺铂后1个月改善至1分。首次给予顺铂后45天患者出院，情况大为改善。副作用为恶心，但可耐受。首次给药6个月后，X线片、内镜及CT检查显示她的癌症消失。她的体能状态评分为0分，第二次给予顺铂后10个月她仍存活，生活质量良好。
