大鼠口服9-顺式视黄酸的排泄情况。
Excretion of oral 9-cis-retinoic acid in the rat.
作者信息
Disdier B, Bun H, Placidi M, Durand A
机构信息
Laboratoire de Toxicologie et Pharmacie Clinique, Faculté de Pharmacie, Marseille, France.
出版信息
Drug Metab Dispos. 1996 Nov;24(11):1279-81.
PMID:8937864
Abstract
We have studied excretion of oral 9-cis-retinoic acid in urine and feces in vigil rats and in bile in anesthetized rats. A proportion of 53 +/- 13% of the dose of 9-cis-retinoic acid administered was eliminated through the feces in 72 hr, and the urinary excretion was negligible. The prevalent form of elimination in feces and urine was the unchanged compound. Low biliary excretion was, for the most part, composed of metabolites.
摘要
我们研究了经口给予9-顺式视黄酸后，清醒大鼠尿液和粪便以及麻醉大鼠胆汁中的排泄情况。给予的9-顺式视黄酸剂量中，有53±13%在72小时内通过粪便排出，而尿液排泄可忽略不计。粪便和尿液中主要的排泄形式是未变化的化合物。胆汁排泄量较低，大部分由代谢产物组成。
Zotero 插件