Tibbs C, Donaldson P, Underhill J, Thomson L, Manabe K, Williams R
Queen Mary's University Hospital, London, England.
Hepatology. 1996 Dec;24(6):1342-5. doi: 10.1053/jhep.1996.v24.pm0008938158.
In the search for factors which may influence susceptibility to and outcome from chronic hepatitis C virus (HCV) infection, few studies have considered the influence of host genes. In the present investigation we have performed HLA DRB1, DQA1, DQB1, and DPB1 genotyping on 104 northern European patients with chronic HCV infection and 177 racially and geographically matched controls. Three HLA class II alleles, DRB10403, DQA103, and DQB10302 were present at a significantly lower frequency in patients compared with controls (4.9% vs. 13%, 20.7% vs. 41.2%, and 11.4% vs. 30.5%, respectively) though only two DQB10302 and DQA1*03 were significant after correction for multiple testing (pc = 0.038, and pc = 0.046, respectively). No further HLA associations with chronic HCV infection were observed and there was no correlation between stage of disease and HLA genotype. These data provide the first suggestion that susceptibility to chronic HCV infection may be influenced by the hosts' HLA DQ alleles.
在寻找可能影响慢性丙型肝炎病毒（HCV）感染易感性及感染结果的因素时，很少有研究考虑宿主基因的影响。在本研究中，我们对104名北欧慢性HCV感染患者和177名种族及地理匹配的对照者进行了HLA DRB1、DQA1、DQB1和DPB1基因分型。与对照者相比，患者中三种HLA II类等位基因DRB10403、DQA103和DQB10302的出现频率显著较低（分别为4.9%对13%、20.7%对41.2%和11.4%对30.5%），不过在进行多重检验校正后，只有DQB10302和DQA1*03具有统计学意义（校正P值分别为0.038和0.046）。未观察到其他HLA与慢性HCV感染的关联，且疾病分期与HLA基因型之间无相关性。这些数据首次表明，慢性HCV感染的易感性可能受宿主HLA DQ等位基因的影响。
