Kales H, Raz J, Tandon R, Maixner D, DeQuardo J, Miller A, Becks L
ECT Program, University of Michigan Medical Center, Ann Arbor 48109-0116, USA.
Psychol Med. 1997 Nov;27(6):1373-80. doi: 10.1017/s0033291797005564.
A relationship between the anticonvulsant and antidepressant properties of electroconvulsive therapy (ECT) has been hypothesized. The goal of this study was to see whether the anticonvulsant effects of ECT could be measured in a clinical setting and whether there was any relationship between the anticonvulsant effects of ECT and the antidepressant response to it.
We examined the temporal relationship between change in seizure duration (as an index of anticonvulsant activity) and improvement in Hamilton Rating Scale for Depression scores in a retrospective sample of 114 depressed patients who received 145 courses of ECT. A linear mixed effects model was utilized for analysis so that the repeated measures nature of the data could be taken into account.
Both seizure duration and depression scores decreased significantly through the course of ECT. However, no evidence was found for a relationship between decrease in seizure duration and clinical improvement as measured by Hamilton ratings.
The process underlying the reduction in seizure duration through a course of ECT may not be related to antidepressant efficacy.
有人提出电休克治疗（ECT）的抗惊厥特性与抗抑郁特性之间存在关联。本研究的目的是了解是否能在临床环境中测量ECT的抗惊厥作用，以及ECT的抗惊厥作用与对其的抗抑郁反应之间是否存在任何关联。
我们在114例接受了145个疗程ECT的抑郁症患者的回顾性样本中，研究了癫痫发作持续时间的变化（作为抗惊厥活性指标）与汉密尔顿抑郁量表评分改善之间的时间关系。采用线性混合效应模型进行分析，以便考虑数据的重复测量性质。
在ECT治疗过程中，癫痫发作持续时间和抑郁评分均显著降低。然而，未发现癫痫发作持续时间的缩短与汉密尔顿评分所衡量的临床改善之间存在关联。
ECT疗程中癫痫发作持续时间缩短的潜在过程可能与抗抑郁疗效无关。
