脑肿瘤的临床正电子发射断层扫描：氟脱氧葡萄糖F 18与L-甲基-11C-蛋氨酸的比较。
Clinical positron emission tomography for brain tumors: comparison of fludeoxyglucose F 18 and L-methyl-11C-methionine.
作者信息
Ogawa T, Inugami A, Hatazawa J, Kanno I, Murakami M, Yasui N, Mineura K, Uemura K
机构信息
Department of Radiology, Research Institute of Brain and Blood Vessels, Akita University School of Medicine, Japan.
出版信息
AJNR Am J Neuroradiol. 1996 Feb;17(2):345-53.
PURPOSE
To evaluate the differences between fludeoxyglucose F 18 (FDG) and L-methyl-11C-methionine (11C-methionine) as tracers for positron emission tomography (PET) in the evaluation of brain tumors.
METHODS
We analyzed 10 patients with histologically verified cerebral glioma or meningioma and 1 patient with a neuroradiologic diagnosis of low-grade glioma by using FDG, 11C-methionine, and PET. We qualitatively and quantitatively evaluated the extent and degree of accumulation of FDG and 11C-methionine in the tumor tissue.
RESULTS
Although PET with FDG depicted malignant tumors as a hot spot in all cases, it was not able to delineate the extent of the tumor. Conversely, PET with 11C-methionine outlined the tumors as areas of increased accumulation of 11C-methionine, regardless of the degree of malignancy.
CONCLUSION
PET with FDG and with 11C-methionine can play complementary roles in the evaluation of brain tumors.
目的
评估氟脱氧葡萄糖F 18（FDG）和L-甲基-11C-蛋氨酸（11C-蛋氨酸）作为正电子发射断层扫描（PET）示踪剂在脑肿瘤评估中的差异。
方法
我们通过使用FDG、11C-蛋氨酸和PET分析了10例经组织学证实的脑胶质瘤或脑膜瘤患者以及1例经神经放射学诊断为低级别胶质瘤的患者。我们对肿瘤组织中FDG和11C-蛋氨酸的积聚程度和范围进行了定性和定量评估。
结果
尽管FDG-PET在所有病例中均将恶性肿瘤描绘为热点，但它无法勾勒出肿瘤的范围。相反，11C-蛋氨酸PET将肿瘤勾勒为11C-蛋氨酸积聚增加的区域，而与恶性程度无关。
结论
FDG-PET和11C-蛋氨酸PET在脑肿瘤评估中可发挥互补作用。
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