Isaka F, Shimizu C, Nakanishi S, Kageyama R
Department of Biological Sciences, Kyoto University Faculty of Medicine, Japan.
Genomics. 1996 Nov 1;37(3):400-2. doi: 10.1006/geno.1996.0577.
It has been shown that mammalian neurogenesis is partly controlled by multiple basic helix-loop-helix (bHLH) genes, as in Drosophila. Recently, mouse homologs of Drosophila atonal, a proneural gene encoding a bHLH protein required for chordotonal organ and photoreceptor development, have been characterized to obtain further insights into the molecular nature of mammalian neurogenesis. Here, to assess their potential involvement in genetic neural disorders, we have determined genetic map positions for four mouse atonal-related genes, Atoh1, Atoh2, Atoh3, and Ndrf, which encode MATH-1, MATH-2, MATH-3, and NDRF, respectively. Interspecific backcross analysis indicated that Atoh1 and Atoh2 were located in separate positions of Chr 6 and that Atoh3 and Ndrf were mapped to Chr 10 and Chr 11, respectively. Thus, these structurally related genes are located separately on multiple chromosomes.
研究表明，与果蝇一样，哺乳动物的神经发生部分受多个碱性螺旋-环-螺旋（bHLH）基因控制。最近，果蝇无调性基因（一种原神经基因，其编码的bHLH蛋白是弦音器官和光感受器发育所必需的）的小鼠同源基因已得到鉴定，以便进一步深入了解哺乳动物神经发生的分子本质。在此，为了评估它们在遗传性神经疾病中的潜在作用，我们确定了四个小鼠无调性相关基因Atoh1、Atoh2、Atoh3和Ndrf的遗传图谱位置，它们分别编码MATH-1、MATH-2、MATH-3和NDRF。种间回交分析表明，Atoh1和Atoh2位于6号染色体的不同位置，Atoh3和Ndrf分别定位于10号染色体和11号染色体。因此，这些结构相关的基因分别位于多条染色体上。
