Soulier C, Baron D, Saraux A, Robert F X, Le Goff P
Rheumatology Department, Morvan Teaching Hospital, Brest, France.
Rev Rhum Engl Ed. 1996 Oct;63(9):593-9.
Collagenous colitis is characterized by chronic watery diarrhea and a greater than 10 micron-thick collagen deposit in the subepithelial layer of the colonic mucosa. Rheumatic and autoimmune diseases have been reported to occur in patients with collagenous colitis. In 1993, we managed four patients with collagenous colitis and joint diseases. One had rheumatoid arthritis, one had a spondylarthropathy and two had seronegative polyarthritis without joint destruction. Three patients had dryness of the eyes and/or mouth and two had Raynaud's phenomenon. These four cases and data from a literature review provide a basis for discussing possible links between collagenous colitis and a number of joint diseases. Although some anecdotal case-reports may reflect a chance association with inflammatory joint diseases, available evidence suggests that collagenous colitis may be a cause of enteropathic arthropathy. Recent data point to an abnormality in the differentiation of fibroblasts in the colonic mucosa, although the mechanism that initiates this abnormality remains unknown.
胶原性结肠炎的特征为慢性水样腹泻以及结肠黏膜上皮下层存在厚度超过10微米的胶原沉积。据报道，风湿性和自身免疫性疾病会在胶原性结肠炎患者中出现。1993年，我们诊治了4例患有胶原性结肠炎及关节疾病的患者。其中1例患有类风湿关节炎，1例患有脊椎关节病，2例患有无关节破坏的血清阴性多关节炎。3例患者有眼干和/或口干症状，2例有雷诺现象。这4个病例以及文献综述中的数据为探讨胶原性结肠炎与多种关节疾病之间可能存在的联系提供了依据。尽管一些个案报道可能反映出与炎性关节疾病的偶然关联，但现有证据表明，胶原性结肠炎可能是肠病性关节炎的病因。近期数据表明结肠黏膜成纤维细胞分化存在异常，不过引发这种异常的机制尚不清楚。
