Soulier C, Saraux A, Baron D, Robert F X, Leroy J P, Le Goff P
Department of Rheumatology, Morvan Teaching Hospital, Brest, France.
Rev Rhum Engl Ed. 1996 Oct;63(9):600-5.
We conducted a prospective cross-sectional study of seven patients with collagenous colitis to determine the clinical, immunologic and histologic features of sicca syndrome associated with this condition. Four patients reported dryness of the mouth and/or eyes. No laboratory evidence of autoimmune disease was found, except in one patient with ankylosing spondylitis. Collagenous infiltration of the salivary glands was quantified in each patient as the percentage of the total gland surface examined. Histologic studies of salivary glands demonstrated significantly more collagen in the group of patients with collagenous colitis than in the group of age-matched controls (30.52% versus 11.8%, p < 0.05). No inflammatory infiltrates were seen. Our data suggest that a common mechanism may underlie the various lesions found in patients with collagenous colitis. However, the mechanism that initiates the fibrotic process in the colon and salivary glands remains unknown.
我们对7例胶原性结肠炎患者进行了一项前瞻性横断面研究，以确定与该疾病相关的干燥综合征的临床、免疫和组织学特征。4例患者报告有口干和/或眼干症状。除1例强直性脊柱炎患者外，未发现自身免疫性疾病的实验室证据。对每位患者的唾液腺胶原浸润情况进行量化，以所检查的腺体总表面积的百分比表示。唾液腺组织学研究显示，胶原性结肠炎患者组的胶原含量明显高于年龄匹配的对照组（30.52%对11.8%，p<0.05）。未观察到炎性浸润。我们的数据表明，一种共同机制可能是胶原性结肠炎患者各种病变的基础。然而，引发结肠和唾液腺纤维化过程的机制仍不清楚。
