Laitinen L A, Laitinen A, Altraja A, Virtanen I, Kämpe M, Simonsson B G, Karlsson S E, Håkansson L, Venge P, Sillastu H
Department of Medicine, University Central Hospital, Helsinki, Finland.
J Allergy Clin Immunol. 1996 Nov;98(5 Pt 2):S3-6; discussion S33-40.
Bronchial biopsy specimens from subjects with intermittent or "early" asthma were compared with specimens taken from healthy subjects. Patients with early asthma included those with seasonal asthma and occupational asthma. There was a small but statistically significant increase in the thickness of the subepithelial extracellular matrix protein tenascin in subjects with seasonal and occupational asthma compared with control subjects. Collagen types IV and VII were increased only in patients with occupational asthma. Eosinophils were the only inflammatory cells that were significantly increased in subjects with seasonal asthma compared with control subjects. These data show that inflammation is present in the airways of patients with early asthma, and the increase in tenascin expression in the basement membrane zone suggests that structural changes are also initiated at an early stage of the disease.
将间歇性或“早期”哮喘患者的支气管活检标本与健康受试者的标本进行了比较。早期哮喘患者包括季节性哮喘和职业性哮喘患者。与对照组相比，季节性和职业性哮喘患者的上皮下细胞外基质蛋白腱生蛋白厚度有小幅但具有统计学意义的增加。IV型和VII型胶原蛋白仅在职业性哮喘患者中增加。与对照组相比，嗜酸性粒细胞是季节性哮喘患者中唯一显著增加的炎症细胞。这些数据表明，早期哮喘患者的气道存在炎症，基底膜区腱生蛋白表达增加表明疾病早期也会引发结构变化。
