p53肿瘤抑制基因的治疗性靶向作用
Therapeutic targeting of the p53 tumor suppressor gene.
作者信息
Beaudry G A, Bertelsen A H, Sherman M I
机构信息
PharmaGenics Inc, 4 Pearl Court, Allendale, NJ 07401, USA.
出版信息
Curr Opin Biotechnol. 1996 Dec;7(6):592-600. doi: 10.1016/s0958-1669(96)80069-3.
PMID:8939636
Abstract
The p53 tumor suppressor gene is a logical target for cancer therapy. Several therapeutic strategies can be envisioned based upon recent advances concerning structure and function of the p53 protein, its interaction with cellular and viral proteins and its roles in repairing DNA, regulating cell division and promoting apoptosis.
摘要
p53肿瘤抑制基因是癌症治疗的一个合理靶点。基于最近关于p53蛋白的结构与功能、其与细胞及病毒蛋白的相互作用以及其在修复DNA、调节细胞分裂和促进细胞凋亡中的作用的进展，可以设想几种治疗策略。
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