Fässler R, Georges-Labouesse E, Hirsch E
Max Planck Institute für Biochemie, Abteilung Proteinchemie, Am Klopferspitz 18A, D-82152 Martinsried, München, Germany.
Curr Opin Cell Biol. 1996 Oct;8(5):641-6. doi: 10.1016/s0955-0674(96)80105-0.
Recent mutations of most integrin genes in the mouse have provided new exciting insights into the role of these integrins in cell-extracellular matrix interactions during development. The embryonic lethal phenotypes obtained by ablating integrins which are predominantly expressed in the mesenchyme confirmed the essential function of those integrins in morphogenesis. In contrast, null alleles for several epithelial integrins which bind components of basement membranes showed milder phenotypes, suggesting the presence of novel and unexpected redundant and compensatory mechanisms.
最近小鼠中大多数整合素基因的突变，为这些整合素在发育过程中细胞与细胞外基质相互作用中的作用提供了令人兴奋的新见解。通过去除主要在间充质中表达的整合素所获得的胚胎致死表型，证实了这些整合素在形态发生中的基本功能。相比之下，几种与基底膜成分结合的上皮整合素的无效等位基因表现出较温和的表型，这表明存在新的、意想不到的冗余和补偿机制。
