Dunon D, Piali L, Imhof B A
Université Pierre et Marie Curie, Centre Nationale de la Recherche Scientifique, URA 1135, Equipe Adhésion et Migration Cellulaire, 9 Quai St Bernard, F-75005 Paris, France.
Curr Opin Cell Biol. 1996 Oct;8(5):714-23. doi: 10.1016/s0955-0674(96)80114-1.
The immune system is formed by leukocytes. They are passively transported through the body by the vascular system, but their entrance into tissues requires a coordinated series of events, namely activation of leukocyte integrins, adhesion to the vascular endothelium, and migration. There are four steps in this process, which begin with the rolling of leukocytes along the vascular endothelium, followed by signaling which activates leukocyte integrins, thus leading to tight adhesion to the endothelium and finally transmigration. Substantial progress has been made recently in elucidating the molecular events that induce rolling and signaling, partly as a result of the study of double-knockout mice that are deficient for genes encoding two selectins.
免疫系统由白细胞构成。它们通过血管系统被动地在体内运输，但它们进入组织需要一系列协调的事件，即白细胞整合素的激活、与血管内皮的黏附以及迁移。这个过程有四个步骤，始于白细胞沿血管内皮滚动，随后是激活白细胞整合素的信号传导，从而导致与内皮紧密黏附，最后是迁移。最近在阐明诱导滚动和信号传导的分子事件方面取得了重大进展，部分原因是对编码两种选择素的基因缺失的双敲除小鼠的研究。
