纺锤体组装检验点
The spindle assembly checkpoint.
作者信息
Rudner A D, Murray A W
机构信息
Department of Physiology, Box 0444, University of California at San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143-0444, USA.
出版信息
Curr Opin Cell Biol. 1996 Dec;8(6):773-80. doi: 10.1016/s0955-0674(96)80077-9.
PMID:8939672
Abstract
The spindle assembly checkpoint monitors proper chromosome attachment to spindle microtubules and is conserved from yeast to humans. Checkpoint components reside on kinetochores of chromosomes and show changes in phosphorylation and localization as cells proceed through mitosis. Adaptation to prolonged checkpoint arrest can occur by inhibitory phosphorylation of Cdc2.
摘要
纺锤体组装检验点监测染色体与纺锤体微管的正确附着，从酵母到人类都保守存在。检验点成分位于染色体的动粒上，并随着细胞进行有丝分裂而在磷酸化和定位上表现出变化。对延长的检验点阻滞的适应可通过Cdc2的抑制性磷酸化发生。
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