Zorick T S, Lemke G
Molecular Neurobiology Laboratory, The Salk Institute, 10010 N Torrey Pines Road, La Jolla, CA 92037, USA.
Curr Opin Cell Biol. 1996 Dec;8(6):870-6. doi: 10.1016/s0955-0674(96)80090-1.
Recent studies of Schwann cell differentiation in vivo and in vitro have provided new insights into determinative signal transduction events both at the cell surface and in the nucleus. Several polypeptide growth factors and their receptors, most notably the neuregulins and receptors of the ErbB family, have been implicated in the specification of cell fate, the control of precursor cell proliferation, and the regulation of programmed cell death during both early and late Schwann cell differentiation. Our understanding of the transcriptional control of Schwann cell development, particularly by the POU protein SCIP and the zinc-finger protein Krox-20, has been advanced by transgenic, knockout, and expression studies.
最近对雪旺细胞在体内和体外分化的研究，为细胞表面和细胞核中决定性信号转导事件提供了新的见解。几种多肽生长因子及其受体，最显著的是神经调节蛋白和ErbB家族受体，在雪旺细胞早期和晚期分化过程中的细胞命运决定、前体细胞增殖控制以及程序性细胞死亡调节中发挥了作用。通过转基因、基因敲除和表达研究，我们对雪旺细胞发育的转录控制，特别是由POU蛋白SCIP和锌指蛋白Krox-20所进行的转录控制，有了更深入的了解。
