Department of Otorhinolaryngology, Head and Neck Tumors, Heidelberg University Hospital, 69120 Heidelberg, Germany.
Research Group Molecular Mechanisms of Head and Neck Tumors, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Cells. 2024 Jan 30;13(3):256. doi: 10.3390/cells13030256.
The neurobiology of tumors has attracted considerable interest from clinicians and scientists and has become a multidisciplinary area of research. Neural components not only interact with tumor cells but also influence other elements within the TME, such as immune cells and vascular components, forming a polygonal relationship to synergistically facilitate tumor growth and progression. This review comprehensively summarizes the current state of the knowledge on nerve-tumor crosstalk in head and neck cancer and discusses the potential underlying mechanisms. Several mechanisms facilitating nerve-tumor crosstalk are covered, such as perineural invasion, axonogenesis, neurogenesis, neural reprogramming, and transdifferentiation, and the reciprocal interactions between the nervous and immune systems in the TME are also discussed in this review. Further understanding of the nerve-tumor crosstalk in the TME of head and neck cancer may provide new nerve-targeted treatment options and help improve clinical outcomes for patients.
肿瘤的神经生物学引起了临床医生和科学家的极大兴趣，并成为一个多学科的研究领域。神经成分不仅与肿瘤细胞相互作用，还影响肿瘤微环境（TME）中的其他元素，如免疫细胞和血管成分，形成多角形关系，协同促进肿瘤生长和进展。本文全面总结了头颈部癌症中神经-肿瘤相互作用的最新知识，并讨论了潜在的潜在机制。本文还讨论了促进神经-肿瘤相互作用的几种机制，如神经周围浸润、轴突发生、神经发生、神经重编程和转分化，以及 TME 中神经系统和免疫系统之间的相互作用。进一步了解头颈部癌症 TME 中的神经-肿瘤相互作用可能为神经靶向治疗提供新的选择，并有助于改善患者的临床预后。
