基质金属蛋白酶与癌症的发展
Matrix metalloproteinases and the development of cancer.
作者信息
Coussens L M, Werb Z
机构信息
Department of Biochemistry and Biophysics, University of California, San Francisco, California 94143-0534, USA.
出版信息
Chem Biol. 1996 Nov;3(11):895-904. doi: 10.1016/s1074-5521(96)90178-7.
PMID:8939708
Abstract
Proteolytic remodeling of the extracellular matrix is an important aspect of the creation and progression of cancer. Matrix metalloproteinases are important at several points during multi-stage neoplastic progression in tumor cells and responding blood vessels, inflammatory cells and stroma.
摘要
细胞外基质的蛋白水解重塑是癌症发生和发展的一个重要方面。基质金属蛋白酶在肿瘤细胞、反应性血管、炎性细胞和基质的多阶段肿瘤进展过程中的多个环节发挥重要作用。
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