蛋白质序列同源性模糊区域的结构解释。
A structural explanation for the twilight zone of protein sequence homology.
作者信息
Chung S Y, Subbiah S
机构信息
Department of Biochemistry, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
出版信息
Structure. 1996 Oct 15;4(10):1123-7. doi: 10.1016/s0969-2126(96)00119-0.
PMID:8939745
Abstract
Homology modeling of protein structures as a function of sequence breaks down at the twilight zone limit of sequence identity between the template and target proteins. Our results suggest that protein sequences that have diverged from a common ancestor beyond the twilight zone may adopt side-chain interactions that are very different from those endowed by the ancestral sequence.
摘要
作为序列函数的蛋白质结构同源性建模在模板蛋白与目标蛋白之间序列同一性的模糊界限处失效。我们的结果表明，在模糊界限之外从共同祖先分化出来的蛋白质序列可能会采用与祖先序列赋予的侧链相互作用非常不同的侧链相互作用。
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