Jelinek T, Löscher T, Nothdurft H D
Department of Infectious Diseases and Tropical Medicine, University of Munich, Germany.
J Infect Dis. 1996 Dec;174(6):1376-9. doi: 10.1093/infdis/174.6.1376.
Circumsporozoite (CS) antibodies, indicating that falciparum malaria infection has occurred, have been shown to be reliable indicators of transmission in malaria-endemic areas. In order to estimate the actual rate of malaria infection, the prevalence of CS antibodies in serum was investigated by ELISA in a selected population of travelers returning from sub-Saharan Africa without any clinical sign of malaria. Sera from 39 (48.8%) of 80 individual travelers were positive, while this was only true for 8 (5.6%) of 142 travelers who took package tours. The risk of malaria infection was therefore 8.7 times greater for individual tourists than for package-tour travelers. These data demonstrate the importance of adequate malaria chemoprophylaxis in nonimmune travelers to areas with highly endemic disease.
环子孢子（CS）抗体表明已发生恶性疟原虫感染，在疟疾流行地区，它已被证明是传播的可靠指标。为了估计疟疾感染的实际发生率，通过酶联免疫吸附测定法（ELISA）对从撒哈拉以南非洲返回且无任何疟疾临床症状的特定旅行者群体血清中的CS抗体患病率进行了调查。80名独自旅行者中有39名（48.8%）血清呈阳性，而在142名跟团旅行者中只有8名（5.6%）血清呈阳性。因此，独自旅行者感染疟疾的风险是跟团旅行者的8.7倍。这些数据证明了在前往疾病高度流行地区的非免疫旅行者中进行充分疟疾化学预防的重要性。
