Christensen M S, Hargens C W, Nacht S, Gans E H
J Invest Dermatol. 1977 Sep;69(3):282-6. doi: 10.1111/1523-1747.ep12507500.
Past attempts to relate mechanical properties of the stratum corneum to its state of hydration or disease condition have been hampered by the lack of adequate in vivo methodology. With the technique described herein, viscoelastic properties of the skin surface can be measured in vivo or on excised skin in vitro. This method is sensitive enough to detect changes in the properties of the stratum corneum induced by topically applied agents or by mechanical disruption of it. The viscoelastic data suggest that the outermost layers of the stratum corneum may become dry in vivo despite their proximity to the underlying wet tissue, and that the instrument is sensitive enough to measure the changes that occur. It also appears that the in vivo behavior of the stratum corneum is similar to that of isolated stratum corneum membranes which become brittle when they are dried and supple when they are hydrated.
过去，由于缺乏足够的体内研究方法，将角质层的力学性能与其水合状态或疾病状况相关联的尝试受到了阻碍。利用本文所述的技术，可以在体内或体外对切除的皮肤上测量皮肤表面的粘弹性。该方法足够灵敏，能够检测局部应用试剂或机械破坏对角质层性能的影响。粘弹性数据表明，尽管角质层的最外层靠近下层湿组织，但在体内可能会变干，并且该仪器灵敏到足以测量所发生的变化。还似乎角质层的体内行为类似于分离的角质层膜，当干燥时变脆，水合时变软。
