McCarthy T J, Dence C S, Holmberg S W, Markham J, Schuster D P, Welch M J
Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Nucl Med Biol. 1996 Aug;23(6):773-7. doi: 10.1016/0969-8051(96)00072-8.
Using positron emission tomography (PET) and nitric oxide radiolabeled with nitrogen-13 (half-life 9.97 min) we probed the distribution and kinetics of inhaled nitric oxide in anesthetized dogs. The washout of this gas after inhalation was much slower than that observed for [13N]nitrogen gas, demonstrating its uptake by lung tissue. The small fraction of radioactivity found in the plasma was determined to be in the form of [13N]nitrate. The administered gas contained < 1 ppm of nonradioactive nitric oxide, which is believed to be below the physiologic threshold for vasorelaxation.
我们使用正电子发射断层扫描（PET）以及用氮 - 13（半衰期9.97分钟）标记的一氧化氮，来探究麻醉犬吸入一氧化氮的分布和动力学。吸入后这种气体的清除比观察到的[13N]氮气慢得多，表明它被肺组织摄取。血浆中发现的少量放射性被确定为[13N]硝酸盐的形式。所给予的气体中含有的非放射性一氧化氮低于1 ppm，据信这低于血管舒张的生理阈值。
