Hantson P, Lievens M, Mahieu P
Cliniques Universitaires St-Luc, Brussels, Belgium.
J Toxicol Clin Toxicol. 1996;34(6):725-30. doi: 10.3109/15563659609013836.
An 86-year-old woman accidentally ingested a preparation containing zinc and copper sulfate. At ninety minutes after ingestion, the peak plasma concentration was 1979 micrograms/dL for zinc and 209 micrograms/dL for copper, suggesting preferential absorption of zinc. The major complications were gastric and bronchial inflammation due to the corrosive properties of these compounds. Systemic manifestations also developed with cardiovascular failure and renal insufficiency, but the patient made a complete recovery. In addition to symptomatic treatment, chelation therapy with dimercaprol and D-penicillamine was given for 48 h.
The available clinical and toxicokinetic data do not support the benefits of chelation in addition to supportive therapy.
一名86岁女性意外摄入了一种含有硫酸锌和硫酸铜的制剂。摄入后90分钟，血浆锌峰值浓度为1979微克/分升，铜峰值浓度为209微克/分升，提示锌的优先吸收。主要并发症是由于这些化合物的腐蚀性导致的胃和支气管炎症。还出现了包括心血管衰竭和肾功能不全在内的全身表现，但患者完全康复。除对症治疗外，给予二巯丙醇和D-青霉胺螯合治疗48小时。
现有的临床和毒代动力学数据不支持除支持性治疗外螯合治疗的益处。
