Krotkiewski M, Brzezinska Z
Department of Rehabilitation Medicine, Sahlgren's Hospital, Gothenburg University, Sweden.
Muscle Nerve. 1996 Dec;19(12):1530-7. doi: 10.1002/(SICI)1097-4598(199612)19:12<1530::AID-MUS2>3.0.CO;2-B.
The antioxidative capacity of slow twitch muscle fibers has been reported to be higher than that of fast twitch ones. The purpose of this study was to relate the production of lipid peroxides during exercise to the morphology and capillarization of human muscles. Twenty-seven healthy volunteers performed a strenuous 90-min exercise. The content of malonyldialdehyde (MDA) in the middle portion of vastus lateralis muscle was found positively correlated with percentage and the relative cross-sectional area of the type 1 of muscle fibers (r = 0.46, P < 0.05, r = 0.43, P < 0.05, respectively) but negatively with type II muscle fibers (r = -0.46, P < 0.05, r = -0.43, P < 0.05, respectively), especially type IIB. The content of MDA in the vastus lateralis muscle correlated positively with the number of capillaries around type II muscle fibers (r = 0.71, P < 0.001). It is suggested that the production of lipid peroxides parallels the exercise-induced increase of oxygen uptake in the muscle, being highest in more oxidative and better perfused, oxygen-consuming muscle fibers.
据报道，慢肌纤维的抗氧化能力高于快肌纤维。本研究的目的是将运动过程中脂质过氧化物的产生与人体肌肉的形态和毛细血管化联系起来。27名健康志愿者进行了90分钟的剧烈运动。发现股外侧肌中部丙二醛（MDA）含量与1型肌纤维的百分比和相对横截面积呈正相关（r分别为0.46，P<0.05；r为0.43，P<0.05），而与II型肌纤维呈负相关（r分别为-0.46，P<0.05；r为-0.43，P<0.05），尤其是IIB型。股外侧肌中MDA含量与II型肌纤维周围的毛细血管数量呈正相关（r=0.71，P<0.001）。提示脂质过氧化物的产生与运动诱导的肌肉摄氧量增加平行，在氧化能力更强、灌注更好、耗氧的肌纤维中最高。
