Ilowite N T
Schneider Children's Hospital, Long Island Jewish Medical Center, New Hyde Park, NY 11040, USA.
Curr Opin Rheumatol. 1996 Sep;8(5):455-8. doi: 10.1097/00002281-199609000-00011.
Premature atherosclerosis is a recognized complication of systemic lupus erythematosus. Atherosclerosis begins in the pediatric age group, and interventions directed toward prevention should begin in childhood as well. A possible cause of premature atherosclerosis is dyslipoproteinemia from the underlying chronic inflammatory disease or from corticosteroid therapy. A relationship between dyslipoproteinemia and anticardiolipin antibodies has been demonstrated. Dietary therapy is helpful, but many patients continue to have significant dyslipoproteinemia after both dietary modification and fish oil supplementation. Lipid-lowering drugs may be indicated in this subgroup. Potential mechanisms of dyslipoproteinemia are discussed.
早发性动脉粥样硬化是系统性红斑狼疮公认的并发症。动脉粥样硬化始于儿童年龄组，针对预防的干预措施也应在儿童期开始。早发性动脉粥样硬化的一个可能原因是潜在慢性炎症性疾病或皮质类固醇治疗引起的血脂蛋白异常血症。血脂蛋白异常血症与抗心磷脂抗体之间的关系已得到证实。饮食疗法是有帮助的，但许多患者在饮食调整和补充鱼油后仍有明显的血脂蛋白异常血症。该亚组患者可能需要使用降脂药物。文中讨论了血脂蛋白异常血症的潜在机制。
