Kohsaka T, Kumazawa M, Yamasaki M, Nakamura H
Department of Endodontics, School of Dentistry, Aichi Gakuin University, Nagoya, Japan.
J Endod. 1996 Aug;22(8):418-21. doi: 10.1016/s0099-2399(96)80243-3.
The purpose of this study was to investigate histologically and histometrically the changes in pulpal periapical tissues after pulpal exposure in streptozotocin-induce diabetic rats. Control rats were injected with citrate buffer. Experimental rats were injected with streptozotocin dissolved in citrate buffer. All animals received a pulpal exposure in the left mandibular first molar. Blood glucose concentration was measured at, 0, 7, 14, 28, and 42 days. All animals were killed at 7, 14, 28, and 42 days after pulpal exposure, and their mandibles were evaluated histologically and histometrically. Blood glucose levels in the experimental rats were significantly higher than those in the control rats. In experimental rats, inflammation in the apical periodontal ligament and root resorption and alveolar bone resorption were more severe than that in control rats. This study also revealed histometrically that, in experimental rats, lesions in the periapical area were significantly larger than those in control rats.
本研究的目的是从组织学和组织计量学角度，调查链脲佐菌素诱导的糖尿病大鼠牙髓暴露后牙髓根尖周组织的变化。对照大鼠注射柠檬酸盐缓冲液。实验大鼠注射溶解于柠檬酸盐缓冲液中的链脲佐菌素。所有动物的左下颌第一磨牙均进行牙髓暴露。在第0、7、14、28和42天测量血糖浓度。所有动物在牙髓暴露后第7、14、28和42天处死，对其下颌骨进行组织学和组织计量学评估。实验大鼠的血糖水平显著高于对照大鼠。在实验大鼠中，根尖牙周膜的炎症、牙根吸收和牙槽骨吸收比对照大鼠更严重。本研究还从组织计量学上显示，实验大鼠根尖区的病变明显大于对照大鼠。
