Yamasaki M, Kumazawa M, Kohsaka T, Nakamura H, Kameyama Y
Department of Endodontics, School of Dentistry, Aichi Gakuin University, Nagoya, Japan.
J Endod. 1994 Jan;20(1):13-7. doi: 10.1016/s0099-2399(06)80020-8.
The purpose of this study was to investigate histologically and histometrically the changes in pulpal and periapical tissues after pulpal exposure in rats. All animals received a pulpal exposure in the left mandibular first molar. Animals were killed at 1 to 56 days after pulpal exposure, and their mandibles were evaluated histologically and histometrically. Histologically, pulpal necrosis extended gradually from the upper part of the pulpal tissue to the apex, with inflammation starting in the periapical tissue at an early stage. As the periapical lesion developed, alveolar bone and cementum resorption was also found. Histometrically, the length of pulpal necrosis increased gradually from 1 to 28 days. The vertical length of the periapical lesion after 14 days was significantly increased, while the horizontal length and the overall area after 7 days were also significantly increased. The periapical lesion extended in a mesiodistal direction at first and then in a vertical direction before expansion ceased.
本研究的目的是从组织学和组织计量学角度研究大鼠牙髓暴露后牙髓和根尖周组织的变化。所有动物的左下颌第一磨牙均进行牙髓暴露。在牙髓暴露后1至56天处死动物，并对其下颌骨进行组织学和组织计量学评估。组织学上，牙髓坏死从牙髓组织上部逐渐延伸至根尖，早期根尖周组织即开始出现炎症。随着根尖周病变的发展，还发现牙槽骨和牙骨质吸收。组织计量学方面，牙髓坏死长度在1至28天逐渐增加。14天后根尖周病变的垂直长度显著增加，而7天后水平长度和总面积也显著增加。根尖周病变最初向近远中方向扩展，然后在垂直方向扩展，直至扩展停止。
