Totté P, Vachiery N, Martinez D, Trap I, Ballingall K T, MacHugh N D, Bensaid A, Wérenne J
Université Libre de Bruxelles, Animal Cell Biotechnology, Faculty of Sciences, Bruxelles, Belgium.
Vet Immunol Immunopathol. 1996 Sep;53(1-2):61-71. doi: 10.1016/0165-2427(96)05603-6.
Recombinant bovine IFN gamma is a potent inhibitor of Cowdria ruminantium growth in vitro irrespective of the rickettsial stock, or the origin of the endothelial cells. These results suggest an important role for IFN gamma in protective immune responses against C. ruminantium infections. Here we also show that IFN gamma can induce the expression of MHC class II molecules on the surface of endothelial cells. However, treatment of endothelial cells with IFN gamma following infection with Cowdria fails to induce MHC class II expression. The implications of this pathogen-specific effect on class II expression by endothelial cells with regard to its recognition by the host immune system are discussed.
重组牛干扰素γ是体外培养的反刍兽考德里氏体生长的有效抑制剂，无论立克次氏体毒株或内皮细胞来源如何。这些结果表明干扰素γ在针对反刍兽考德里氏体感染的保护性免疫反应中起重要作用。我们还在此表明，干扰素γ可诱导内皮细胞表面MHC II类分子的表达。然而，在用反刍兽考德里氏体感染后用干扰素γ处理内皮细胞并不能诱导MHC II类表达。本文讨论了这种病原体特异性效应在内皮细胞II类表达方面对宿主免疫系统识别的影响。
