诺氟沙星在溶液、原料药及片剂中的光化学稳定性。
Photochemical stability of norfloxacin in solutions, bulk form and tablets.
作者信息
al-Deeb O A, Abdel-Moety E M, Abounassif M A, Alzaben S R
机构信息
Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
出版信息
Boll Chim Farm. 1996 Jun;135(6):397-400.
Accelerated photochemical degradation of norfloxacin in solutions, bulk forms, and tablets has been undertaken. The kinetic order of the drug photodegradation was determined by monitoring residual drug masses as a function of time matched with initial matched mass by adopting the HPLC-method of USP-23. A new dimeric photodegradate, formed from the active decarboxylated norfloxacin monomer, could be isolated and characterized.
已对诺氟沙星在溶液、原料药及片剂中的加速光化学降解进行了研究。采用美国药典23版的高效液相色谱法，通过监测残留药物质量随时间的变化，并与初始匹配质量进行对比，确定了药物光降解的动力学级数。一种由活性脱羧诺氟沙星单体形成的新型二聚体光降解产物得以分离并进行了表征。
Zotero 插件