Worthington J, Fava M, Agustin C, Alpert J, Nierenberg A A, Pava J A, Rosenbaum J F
Depression Research Program, Clinical Psychopharmacology Unit, Massachusetts General Hospital, Boston 02114, USA.
Psychosomatics. 1996 Nov-Dec;37(6):518-22. doi: 10.1016/S0033-3182(96)71515-3.
The authors present findings from the first investigation of the use of alcohol, nicotine, and caffeine in nonsubstance-abusing outpatients with major depressive disorder. The patients (N = 94) were assessed for their intake of alcohol, nicotine, and caffeine, and then treated openly for 8 weeks with 20 mg/day of fluoxetine. The degree of alcohol consumption at baseline was a significant predictor of poorer response to the antidepressant. This relationship remained significant even after adjusting for severity of depression at baseline. Even moderate levels of alcohol consumption appear to negatively affect pharmacologic treatment in depressed outpatients.
作者介绍了对非物质滥用的重度抑郁症门诊患者使用酒精、尼古丁和咖啡因情况的首次调查结果。对94名患者评估了他们酒精、尼古丁和咖啡因的摄入量，然后采用每天20毫克氟西汀进行为期8周的公开治疗。基线时酒精摄入量是对抗抑郁药反应较差的一个重要预测指标。即使在对基线时的抑郁严重程度进行校正后，这种关系仍然显著。即使是适度的酒精消费似乎也会对抑郁症门诊患者的药物治疗产生负面影响。
