Hoek H W, Susser E, Buck K A, Lumey L H, Lin S P, Gorman J M
Rosenburg Psychiatric Institute, The Hague, The Netherlands.
Am J Psychiatry. 1996 Dec;153(12):1637-9. doi: 10.1176/ajp.153.12.1637.
The authors tested whether early prenatal exposure to famine was associated with schizophrenia spectrum personality disorder in addition to being associated with schizophrenia per se as shown in a previous study.
The risk of schizoid personality disorder, as defined by ICD-6 to ICD-9, in men at age 18 years was compared in birth cohorts that were conceived at the height of the Dutch Hunger Winter famine and in unexposed birth cohorts of 1944-1946 in the famine region of Holland.
The exposed cohort had a significantly greater risk (relative risk = 2.01) of schizoid personality disorder.
Prenatal nutritional deficiency was associated with a greater risk of schizoid personality disorder in men at age 18 years.
如先前研究所表明的，作者测试了产前早期暴露于饥荒环境除了与精神分裂症本身相关外，是否还与精神分裂症谱系人格障碍有关。
比较了在荷兰饥荒冬季高峰期受孕的出生队列以及1944 - 1946年荷兰饥荒地区未暴露的出生队列中18岁男性患分裂样人格障碍（根据国际疾病分类第6版至第9版定义）的风险。
暴露队列患分裂样人格障碍的风险显著更高（相对风险 = 2.01）。
产前营养缺乏与18岁男性患分裂样人格障碍的风险增加有关。
