Bear M F
Department of Neuroscience, Brown University, Providence, RI 02912, USA.
Proc Natl Acad Sci U S A. 1996 Nov 26;93(24):13453-9. doi: 10.1073/pnas.93.24.13453.
A cardinal feature of neurons in the cerebral cortex is stimulus selectivity, and experience-dependent shifts in selectivity are a common correlate of memory formation. We have used a theoretical "learning rule," devised to account for experience-dependent shifts in neuronal selectivity, to guide experiments on the elementary mechanisms of synaptic plasticity in hippocampus and neocortex. These experiments reveal that many synapses in hippocampus and neocortex are bidirectionally modifiable, that the modifications persist long enough to contribute to long-term memory storage, and that key variables governing the sign of synaptic plasticity are the amount of NMDA receptor activation and the recent history of cortical activity.
大脑皮层神经元的一个主要特征是刺激选择性，而选择性的经验依赖性变化是记忆形成的常见关联因素。我们使用了一种理论上的“学习规则”，该规则旨在解释神经元选择性的经验依赖性变化，以指导关于海马体和新皮层突触可塑性基本机制的实验。这些实验表明，海马体和新皮层中的许多突触是双向可修饰的，这些修饰持续的时间足够长，足以促进长期记忆存储，并且控制突触可塑性正负的关键变量是NMDA受体激活量和皮层活动的近期历史。
