• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Inhibition of Trypanosoma cruzi and T. brucei NADH fumarate reductase by benznidazole and anthelmintic imidazole derivatives.

作者信息

Turrens J F, Watts B P, Zhong L, Docampo R

机构信息

Department of Biomedical Sciences, University of South Alabama, Mobile 36688-0002, USA.

出版信息

Mol Biochem Parasitol. 1996 Nov 12;82(1):125-9. doi: 10.1016/0166-6851(96)02722-3.

DOI:10.1016/0166-6851(96)02722-3
PMID:8943158
Abstract
摘要

相似文献

1
Inhibition of Trypanosoma cruzi and T. brucei NADH fumarate reductase by benznidazole and anthelmintic imidazole derivatives.
Mol Biochem Parasitol. 1996 Nov 12;82(1):125-9. doi: 10.1016/0166-6851(96)02722-3.
2
Rotenone at high concentrations inhibits NADH-fumarate reductase and the mitochondrial respiratory chain of Trypanosoma brucei and T. cruzi.
Mol Biochem Parasitol. 1998 May 15;93(1):135-7. doi: 10.1016/s0166-6851(98)00015-2.
3
Mercaptopyridine-N-oxide, an NADH-fumarate reductase inhibitor, blocks Trypanosoma cruzi growth in culture and in infected myoblasts.
FEMS Microbiol Lett. 1999 Jun 15;175(2):217-21. doi: 10.1111/j.1574-6968.1999.tb13623.x.
4
Crassiflorone derivatives that inhibit Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase (TbGAPDH) and Trypanosoma cruzi trypanothione reductase (TcTR) and display trypanocidal activity.抑制布氏锥虫甘油醛-3-磷酸脱氢酶（TbGAPDH）和克氏锥虫锥虫硫氧还蛋白还原酶（TcTR）并具有杀锥虫活性的厚花素衍生物。
Eur J Med Chem. 2017 Dec 1;141:138-148. doi: 10.1016/j.ejmech.2017.10.005. Epub 2017 Oct 3.
5
Targeting the substrate preference of a type I nitroreductase to develop antitrypanosomal quinone-based prodrugs.针对 I 型硝基还原酶的底物偏好性，开发基于醌类的抗锥虫前药。
Antimicrob Agents Chemother. 2012 Nov;56(11):5821-30. doi: 10.1128/AAC.01227-12. Epub 2012 Sep 4.
6
Activation of benznidazole by trypanosomal type I nitroreductases results in glyoxal formation.苯唑达唑被原生动物型 I 硝基还原酶激活后会形成乙二醛。
Antimicrob Agents Chemother. 2012 Jan;56(1):115-23. doi: 10.1128/AAC.05135-11. Epub 2011 Oct 28.
7
In vitro evaluation of arylsubstituted imidazoles derivatives as antiprotozoal agents and docking studies on sterol 14α-demethylase (CYP51) from Trypanosoma cruzi, Leishmania infantum, and Trypanosoma brucei.芳基取代咪唑衍生物作为抗原生动物药物的体外评价以及对克氏锥虫、婴儿利什曼原虫和布氏锥虫的甾醇14α-脱甲基酶（CYP51）的对接研究。
Parasitol Res. 2019 May;118(5):1533-1548. doi: 10.1007/s00436-019-06206-z. Epub 2019 Mar 23.
8
Toward the development of dual-targeted glyceraldehyde-3-phosphate dehydrogenase/trypanothione reductase inhibitors against Trypanosoma brucei and Trypanosoma cruzi.朝着开发针对布氏锥虫和克氏锥虫的双靶点甘油醛-3-磷酸脱氢酶/锥虫硫醇还原酶抑制剂的方向发展。
ChemMedChem. 2014 Feb;9(2):371-82. doi: 10.1002/cmdc.201300399. Epub 2014 Jan 8.
9
Synergistic activity of 5-substituted 2-nitroimidazoles (Ro 15-0216 and benznidazole) and DL-alpha-difluoromethylornithine on Trypanosoma brucei brucei.5-取代-2-硝基咪唑（Ro 15-0216和苄硝唑）与DL-α-二氟甲基鸟氨酸对布氏布氏锥虫的协同活性。
Ann Soc Belg Med Trop. 1990 Dec;70(4):269-79.
10
Imidazole and nitroimidazole derivatives as NADH-fumarate reductase inhibitors: Density functional theory studies, homology modeling, and molecular docking.咪唑和硝基咪唑衍生物作为 NADH-琥珀酸还原酶抑制剂：密度泛函理论研究、同源建模和分子对接。
J Comput Chem. 2022 Sep 5;43(23):1573-1595. doi: 10.1002/jcc.26959. Epub 2022 Jul 7.

引用本文的文献

1
Imidazole and nitroimidazole derivatives as NADH-fumarate reductase inhibitors: Density functional theory studies, homology modeling, and molecular docking.咪唑和硝基咪唑衍生物作为 NADH-琥珀酸还原酶抑制剂：密度泛函理论研究、同源建模和分子对接。
J Comput Chem. 2022 Sep 5;43(23):1573-1595. doi: 10.1002/jcc.26959. Epub 2022 Jul 7.
2
Experimental and Clinical Treatment of Chagas Disease: A Review.恰加斯病的实验与临床治疗综述
Am J Trop Med Hyg. 2017 Nov;97(5):1289-1303. doi: 10.4269/ajtmh.16-0761. Epub 2017 Oct 10.
3
Nitrotriazole-based acetamides and propanamides with broad spectrum antitrypanosomal activity.
具有广谱抗锥虫活性的基于硝基三唑的乙酰胺和丙酰胺。
Eur J Med Chem. 2016 Nov 10;123:895-904. doi: 10.1016/j.ejmech.2016.08.002. Epub 2016 Aug 9.
4
Megazol and its bioisostere 4H-1,2,4-triazole: comparing the trypanocidal, cytotoxic and genotoxic activities and their in vitro and in silico interactions with the Trypanosoma brucei nitroreductase enzyme.美拉唑及其生物电子等排体4H-1,2,4-三唑：比较杀锥虫、细胞毒性和遗传毒性活性及其与布氏锥虫硝基还原酶的体外和计算机模拟相互作用。
Mem Inst Oswaldo Cruz. 2014 Jun;109(3):315-23. doi: 10.1590/0074-0276140497. Epub 2014 Mar 18.
5
Novel 3-nitro-1H-1,2,4-triazole-based aliphatic and aromatic amines as anti-chagasic agents.新型 3-硝基-1H-1,2,4-三唑基脂肪族和芳香族胺类化合物作为抗恰加斯病药物。
J Med Chem. 2011 Dec 8;54(23):8214-23. doi: 10.1021/jm201215n. Epub 2011 Nov 4.
6
Mitochondrial bioenergetics and redox state are unaltered in Trypanosoma cruzi isolates with compromised mitochondrial complex I subunit genes.线粒体生物能量学和氧化还原状态在克氏锥虫分离株中未发生改变，这些分离株的线粒体复合体I亚基基因存在缺陷。
J Bioenerg Biomembr. 2009 Jun;41(3):299-308. doi: 10.1007/s10863-009-9228-4. Epub 2009 Jul 18.