Chen C S, Chu S H, Lai Y M, Wang M L, Chan P R
Department of Surgery, Chang Gung Memorial Hospital, Taipei, Taiwan.
Hum Reprod. 1996 Oct;11(10):2176-9. doi: 10.1093/oxfordjournals.humrep.a019072.
To determine the possibility of finding motile spermatozoa and spermatids in patients with high serum follicle stimulating hormone (FSH) and spermatogenetic disorders proven by pathology, 100 cases of male infertility were reviewed. Of these, 71 patients were found to have non-obstructive azoospermia or severe primary spermatogenetic disorders, and 20 had obstructive azoospermia. A prospective study of the most recent 51 cases was conducted. Multiple testicular tissue biopsies were examined by a pathologist and a well-trained gynaecological technician. The findings of spermatozoa, spermatids and serum FSH concentrations were compared among six different histological groups. It was concluded that 51.2% of the non-obstructive azoospermic and failed spermatogenetic patients had spermatids and even motile 'shaking' spermatozoa and should be re-evaluated. In the non-obstructive azoospermic patients here, almost all the motile spermatozoa and spermatids were found in patients with a serum FSH concentration of < 30 mIU/ml. It is suggested that a testicular biopsy should be conducted in every case of non-obstructive azoospermia and spermatogenetic disorder, even in those patients with elevated serum FSH concentrations.
为了确定在血清卵泡刺激素（FSH）水平升高且经病理证实存在生精障碍的患者中发现活动精子和精子细胞的可能性，回顾性分析了100例男性不育患者。其中，71例患者被发现患有非梗阻性无精子症或严重的原发性生精障碍，20例患有梗阻性无精子症。对最近的51例患者进行了前瞻性研究。由一名病理学家和一名训练有素的妇科技术员对多次睾丸组织活检进行检查。比较了六个不同组织学组中精子、精子细胞的发现情况以及血清FSH浓度。得出的结论是，51.2%的非梗阻性无精子症和生精失败患者有精子细胞，甚至有活动的“摆动”精子，应重新评估。在此处的非梗阻性无精子症患者中，几乎所有活动精子和精子细胞都见于血清FSH浓度<30 mIU/ml的患者。建议对每例非梗阻性无精子症和生精障碍患者进行睾丸活检，即使是那些血清FSH浓度升高的患者。
