疟原虫色素是抗疟药物的作用靶点吗？

Is haemozoin a target for antimalarial drugs?

作者信息

Meshnick S R

机构信息

Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor 48109-2029, USA.

出版信息

Ann Trop Med Parasitol. 1996 Aug;90(4):367-72. doi: 10.1080/00034983.1996.11813065.

DOI:10.1080/00034983.1996.11813065

PMID:8944080

Abstract

Malarial parasites utilize a unique pathway to degrade haemoglobin. Most of the haem which is released during haemoglobin degradation is incorporated into haemozoin. The mechanism of haemozoin synthesis and the structure of haemozoin are controversial. Neither chloroquine nor artemisinin appear to affect haemozoin synthesis in vivo. Artemisinin is activated by intraparasitic haem and iron into a free radical which then alkylates specific malarial proteins.

摘要

疟原虫利用一种独特的途径来降解血红蛋白。血红蛋白降解过程中释放的大部分血红素会被整合到疟色素中。疟色素的合成机制和结构存在争议。氯喹和青蒿素在体内似乎都不影响疟色素的合成。青蒿素被寄生体内的血红素和铁激活形成自由基，然后使特定的疟原虫蛋白质烷基化。