三氧喹啉和血红素-青蒿素加合物在体外对疟原虫疟色素形成的抑制作用比氯喹更好。
Trioxaquines and heme-artemisinin adducts inhibit the in vitro formation of hemozoin better than chloroquine.
作者信息
Loup Christophe, Lelièvre Joël, Benoit-Vical Françoise, Meunier Bernard
机构信息
Laboratoire de Chimie de Coordination, CNRS, 205 Route de Narbonne, 31000, Toulouse Cedex 4, France.
出版信息
Antimicrob Agents Chemother. 2007 Oct;51(10):3768-70. doi: 10.1128/AAC.00239-07. Epub 2007 Aug 13.
Abstract
Trioxaquines, potential antimalarial agents, and heme-artemisinin adducts, resulting from the alkylation of heme by artemisinin, were evaluated as inhibitors of beta-hematin formation in 10 M acetate medium at pH 5.
摘要
三氧喹啉类潜在抗疟药以及由青蒿素使血红素烷基化产生的血红素 - 青蒿素加合物，在pH值为5的10 M乙酸盐介质中被评估为β - 血红素形成的抑制剂。
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本文引用的文献
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