Pou Serradell A, Royo I, Aragones J M, Zapater E, Pañella A
Service de Neurologie, Hôpital del Mar, Barcelona.
Rev Neurol (Paris). 1996 Jun-Jul;152(6-7):483-5.
We report a case of polyneuropathy caused by primary Epstein Barr virus (EBV) infection in a 57-year-old patient. The primary EBV infection was confirmed by serology tests and EBNA (Epstein-Barr nuclear antigen) seroconversion. The main clinical sign was a highly painful subacute, bilateral lumbar radiculoplexopathy with amyotrophy which responded to corticosteroids and complement treatment within a few months. The association of left facial paralysis, neurophysiological signs of polyradiculopathy and elevated protein levels in the cerebrospinal fluid demonstrate the variability of peripheral neurological involvement in the same subject with EBV infection. This case also demonstrates the poorly limits of dysimmune polyneuropathies, including lumbar radiculoplexopathy which can be considered as an exceptional variant.
我们报告了一例57岁患者因原发性爱泼斯坦-巴尔病毒(EBV)感染引起的多发性神经病。原发性EBV感染通过血清学检测和EBNA(爱泼斯坦-巴尔核抗原)血清学转换得以确诊。主要临床症状为高度疼痛的亚急性双侧腰神经根丛病伴肌萎缩,在数月内对皮质类固醇和补充治疗有反应。左侧面神经麻痹、神经根病的神经生理学体征以及脑脊液中蛋白质水平升高,表明同一EBV感染患者外周神经受累的变异性。该病例还表明免疫失调性多发性神经病的界限不明确,包括可被视为一种特殊变异型的腰神经根丛病。