Eltumi M, Brueton M J, Francis N
Academic Department of Child Health, Charing Cross and Westminster Medical School, Chelsea and Westminster Hospital, London.
Gut. 1996 Oct;39(4):613-4. doi: 10.1136/gut.39.4.613.
Ulceration of the small intestine in children has not been previously described.
Two children, aged 12 and 18 months, presented with a history of failure to thrive and intractable diarrhoea.
Upper gastrointestinal endoscopy showed multiple ulcers involving the first and second parts of the duodenum. Histology of biopsy specimens taken from these sites confirmed ulceration and showed other features consistent with a diagnosis of coeliac disease. They both showed pronounced clinical improvement and satisfactory linear growth on a gluten free diet. A year later the diagnosis of coeliac disease was confirmed on a biopsy controlled gluten challenge, and repeat endoscopy showed complete resolution of the intestinal ulceration.
此前尚未有关于儿童小肠溃疡的描述。
两名儿童，年龄分别为12个月和18个月，有发育不良和顽固性腹泻病史。
上消化道内镜检查显示十二指肠第一部和第二部有多处溃疡。取自这些部位的活检标本组织学检查证实为溃疡，并显示出与乳糜泻诊断相符的其他特征。他们在无麸质饮食后均表现出明显的临床改善和令人满意的线性生长。一年后，在活检控制的麸质激发试验中确诊为乳糜泻，再次内镜检查显示肠道溃疡完全消退。
