Collett K, Hartveit F, Skjaerven R, Maehle B O
Gade Institute, Department of Pathology, University of Bergen, Haukeland Hospital, Norway.
J Clin Pathol. 1996 Nov;49(11):920-5. doi: 10.1136/jcp.49.11.920.
To consider the prognostic role of oestrogen receptor and progesterone receptor status in relation to the age at surgery, length of follow up and lymph node status.
The study population comprised 977 patients with histologically confirmed breast carcinoma, with a median follow up of nine years. The actuarial life table method was used to test for survival differences. The Cox proportional hazard model was used to test for interaction effects between each hormone receptor and age, lymph node status and length of follow up. As the analysis involved multiple subgroups, significance was set at the 1% level (p < 0.01).
When the patients were subdivided into groups according to lymph node status and age, progesterone and oestrogen receptor status predicted prognosis in middle aged (46-60 years) patients with lymph node positive breast cancer. Their prognostic effect in this subgroup, however, was restricted to the first five years after surgery. Progesterone receptor status was the strongest predictor of outcome.
The prognostic power of oestrogen and progesterone receptor status varies depending on age, lymph node status and length of follow up after surgery.
探讨雌激素受体和孕激素受体状态与手术年龄、随访时间及淋巴结状态相关的预后作用。
研究人群包括977例经组织学确诊的乳腺癌患者，中位随访时间为9年。采用精算生命表法检验生存差异。使用Cox比例风险模型检验每种激素受体与年龄、淋巴结状态及随访时间之间的交互作用。由于分析涉及多个亚组，显著性设定为1%水平（p < 0.01）。
当根据淋巴结状态和年龄将患者分组时，孕激素和雌激素受体状态可预测中年（46 - 60岁）淋巴结阳性乳腺癌患者的预后。然而，它们在该亚组中的预后作用仅限于术后的前五年。孕激素受体状态是结局的最强预测指标。
雌激素和孕激素受体状态的预后能力因年龄、淋巴结状态及术后随访时间而异。
